Trending Bilirubin

BiliTool can trend bilirubin over time with comma separated sequential results to reveal the rate of change (ROC), especially a rapid increase to help identify infants at risk of developing hyperbilirubinemia.

The 2022 AAP Guideline (see KAS 7) has established a rapid rate of increase as ≥ 0.3 mg/dL (5.1 µmol/L) in the first 24 hours or ≥ 0.2 mg/dL (3.4 µmol/L) after 24 hours.

A portion of the BiliTool entry page showing the option of entering single or sequential data for newborn hours of age and bilirubin values.
Figure 1 of 2. A portion of the BiliTool entry page showing the option of entering single or sequential data for newborn hours of age and bilirubin values.
Steps:

If more than one bilirubin result is avaiable, enter the following in chronological order, separated by a comma:

  1. The prior age (in hours) at sample collection followed by the most recent age at collection..
  2. The prior bilirubin result, followed by the most recent bilirubin.
  • The last age/bilirubin dataset evaluates the treatment thresholds, escalation of care, reflex testing, postdischarge recommendations, etc.
  • The last two paired age/bilirubin datasets are used to establish the rate of change.
  • While you may enter three or more datasets, only the last two are evaluated. We will enable the display of all entered datasets on the BiliGraph in an upcoming release.
  • On the results page, a trending arrow in the direction of change will change color from green to red if the ROC falls within the rapid rate of increase thresholds established by the AAP (see above). It may also include a brief recommendation (e.g. to perform a Direct Antiglobulin Test (DAT)).
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Figure 2 of 2. The results page showing the bilirubin trend and a green arrow indicating the rate of increase is within normal limits.